Effects of oral calcium carbonate on blood pressure in subjects with mildly elevated arterial pressure
Recent investigations suggest that calcium supplementation may cause a lower arterial pressure in hypertensive individuals. We studied 32 patients with mildly elevated arterial pressure (diastolic pressure 88-95 mmHg) and inadequate dietary calcium intake (less than 750 mm/day), who were randomly assigned to placebo or 1500 mg/day elemental calcium for 4 weeks. Baseline and post-treatment urinary calcium concentrations and 3 biweekly supine blood pressures were recorded. Supine systolic blood pressure in the calcium group rose during the first 2 weeks of treatment (delta systolic blood pressure +5.9 mmHg; P less than 0.025) compared with no change in supine blood pressure for the placebo group. Within the calcium group, seven out of 15 patients had decreased or unchanged supine blood pressure during treatment. A lower urinary calcium concentration and a lower dietary sodium intake were found in this subgroup compared with those whose supine blood pressure increased with calcium administration.
High Blood Pressure: Over-the-Counter Medicines to Avoid
Which over-the-counter medicines can affect blood pressure?
Some over-the-counter (OTC) medicines can raise your blood pressure or keep your blood pressure medicine from working the way it should. So if you have high blood pressure or other heart or blood vessel problems, you need to be careful with OTC medicines. That includes vitamins and supplements. Your doctor or pharmacist can suggest OTC medicines that are safe for you.
Some common types of OTC medicines you may need to avoid include:
- Decongestants, such as those that contain pseudoephedrine.
- Pain medicines (NSAIDs), such as ibuprofen and naproxen.
- Cold and flu medicines. These often contain decongestants and NSAIDs.
- Some antacids and other stomach medicines. Many of these are high in sodium, which can raise blood pressure. So be sure to read labels carefully to check for sodium content.
- Some herbal remedies and dietary supplements. Examples are ephedra, ma huang, and bitter orange.
How can you know if it's safe to take an over-the-counter medicine?
Always talk with your pharmacist or doctor before you take any new OTC medicine or supplement. He or she can:
- Check to make sure that the medicine won't interact with your blood pressure medicine.
- Suggest OTC medicines that won't affect your blood pressure.
It's also important to make a list of all the medicines you take. Bring it to each appointment, and ask your doctor to review it. Be sure to include all your prescription medicines, OTC medicines, vitamins, and herbal and dietary supplements.
Current as of: August 31, 2020
Author: Healthwise Staff
Medical Review: Kathleen Romito MD - Family Medicine
Adam Husney MD - Family Medicine
Adam Husney MD - Family Medicine
Are You Popping Tums Like Candy? Why This May Be Detrimental to Your Health.
"What do you do if you have heartburn or indigestion?"
"Take Tums, of course."
Well, it's time to think twice about this answer.
Taking Tums or other antacids for heartburn has become second nature. It has become the adult version of smarties, yes those small little candy tablets you used to eat as a child and pretend they were medicine. Oh, how the times have changed: now we use medicine like it's candy.
Heartburn usually occurs when a muscle, called the lower esophageal spincture, does not close completely, allowing stomach contents to regurgitated from the stomach into the esophagus.This muscle acts like a valve, opening to allow food from the esophagus into the stomach, and closing to prevent the backflow of contents from the stomach into the esophagus, but with every valve comes the potential for leaks, and in this case heartburn. Part of the contents regurgitated include gastric acid (hydrochloric acid), which is usually the main culprit behind that burning sensation. It is this acid that can lead to corrossion and excessive inflammtion, after all as it's name implies it is an acid.
While tums aren't harmful, when taken in excess they can be detrimental to our health. Tums are calcuim carbonate, a basic compound that is used to neutralize gastric acid (the acid I mentioned aboved that is produced in your stomach). Gastric acid is present in our stomach's for a few reasons. One being, it is a main component in digestion and breaking down our foods. Without it, we would not be able to absorb the vitamins and minerals essential for the body to function. The constant neutralization of this acid puts you at a higher risk of vitamin deficiencies and it's sequela such as fatigue, constipation, muscle weakness and pain. Another reason why gastric acid is present is for protection. This acid is the body's first line of defensive against harmful bacteria, viruses, parasites, and pathogens. By reducing it, you are making yourselves more susceptible to infections. Tums, as mentioned, also contains calcium which is absorbed into the body. Although calcium is vital for the bones and overall good health, too much calcium is dangerous and can lead to heart and kidney problems. Some symptoms of increased calcium in the body include palpitations, high blood pressure, abnormal heart rhythms, headaches, constipation, abdominal pain, fatigue, increased thirst and frequent urination.
Now that we went over some of the basic physiology and mechanisms of action involved in heartburn, lets talk about some risk factors that can be causing or worsening symptoms.
1. Obesity. Extra weight can put unwanted pressure on the esophageal spincture causing it to open when it shouldn't. While loosing weight is, by far, not the easiest of things to do, it is the best thing you can do if you are overweight and suffering from heartburn.
2. Smoking. Once again is it not the easiest to stop smoking, but it is one of the best things that you can do for acid reflux, amongst many other health concerns.
3. Low levels of physical activity. We all know that exercise has a drastic affect on multiple avenues of our health, but many do not know that lack of exercise can cause heartburn. Increasing daily movement, can help decrease heartburn.
4. Medications. Some of the most common medications that causes heartburn are muscle relaxers. Muscle relaxers can cause the esophageal sphincture to relax worsen that backflow leak.
5. Hernias and pregnancy are also common causes of heartburn.
Seven strategies that can help reduce heartburn and decrease the amount of antacids you are consuming.
1. Allow 2-3 hours after eating before laying down.
2. Eat 4-6 smaller meals throughout the day, rather than 2-3 larger meals. This will help ensure that gastric acid does not go unopposed in the stomach, but rather has food to digest.
3. Eliminate caffeine and alcohol as these are big acid reflux culprits. Other common triggers include chocolate, citrus, mint, tomatoes, black pepper, garlic, onions, spicy foods, and fatty foods.
4. Know your food sensititivies. While the aboved mentioned foods are common causes of heartburn, problem foods can differ from person to person. Food sensitivities can lead to inflammation and a cascade of stomach and intestinal symptoms.
5. Eliminate carbinated drinks. Excess bubbles can lead to an increase in gas and acid reflux.
6. Try DGL (Deglycyrrhizinated Licorice) instead of antacids. Licorice has been show to alleviate acid reflux symptoms. It may also protect the stomach and esophagus from acid by increasing mucus production. DGL is a form of licorice that has substantial amounts of glycyrrhizan removed. Glycyrrhizan is the component in licorice that can increase blood pressure. Always make sure that the DGL bottle has less than 3% glycyrrhizan. Always consult your doctor before taking any supplements.
7. Marshmallow Tea. In the herbal world, marshmallow is classified as a delmulcent, meaning it decreases inflammation by forming a barrier in the gastrointestinal tract against irritants such as stomach acid, ie your very own marshmellow fort against stomach acid. For our organic, physician formulated loose leaf tea visit www.healingessencestore.com.
Lastly, while I do believe that Tums (or equivalent antacids) should be a staple in everyone's medicine chest, they should be used sparingly. Think of them like bandaids; great for short term use. It is important to seek medical help if you are suffering from pronlonged heartburn to figure out the cause, and treat accordingly. Click here to book your appointment today.
P.S. If you are frequently taking Tums or another calcium carbonate antacid, do not forget to tell your doctor, especially before running any bloodwork. Frequent consumption may show an increase in calcium levels on blood work.
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Calcium Supplements and High Blood Pressure Medications
Calcium supplements are generally safe and are not likely to affect your blood pressure, at least not directly. However, if you are being treated for hypertension, calcium supplements may indirectly cause your blood pressure to rise by interfering with your medication's effects.
Calcium supplements can interfere with the action of certain high blood pressure medications, making them less effective at controlling blood pressure. In this case, the calcium isn’t actually causing your blood pressure to rise; rather, it is stopping your medications from exerting their blood-pressure-lowering effects.
These interactions are uncommon, and only affect a small number of high blood pressure medicines. The two blood pressure-lowering medications that are most likely to interact with calcium supplements are thiazide diuretics and calcium channel blockers. Here is how calcium supplements can interfere with those two types of medication.
Thiazide diuretics work to lower your blood pressure by helping your kidneys get rid of excess water and sodium (rather than holding on to it). Lowering the volume of fluid in your bloodstream relieves some of the pressure, making it easier for your heart to pump.
In some cases, taking calcium with a thiazide diuretic can lead to a condition called milk-alkali syndrome in which the body becomes less acidic and blood calcium levels begin to rise. This can lead to hypercalcemia (abnormally high blood calcium), the condition of which increases the risk of heart attack, acute kidney failure, and seizure.
If taking a thiazide diuretic, you should restrict your calcium intake to less than 1,500 milligrams (mg) per day.
How Hyperkalemia Is Treated
Calcium Channel Blockers
Calcium channel blockers help lower blood pressure this way: they stop calcium from interacting with blood vessels, which lowers the blood vessel’s ability to tighten and ultimately leads to looser vessels and lower blood pressure.
It makes sense, then, that calcium channel blockers can also be affected by calcium supplements. However, there's typically only a risk when you're getting extremely high levels of supplemented calcium (such as being given high doses of calcium through IV in a hospital).
In this case, the interaction is very straightforward: very high levels of blood calcium can “out-compete” the drug’s ability to block the interaction between calcium and your blood vessels. In essence, there is so much calcium that the drug simply cannot block it all. When this happens, it can be quickly reversed by stopping the IV administration of calcium.
There is no evidence that oral calcium supplements can interfere with calcium channel blockers. However, to be safe, check your blood pressure regularly if taking calcium supplements and calcium channel blockers together.
Best and Worst Calcium Supplements
Other Blood Pressure Medications
Calcium supplements do not interfere with other common blood pressure medications like ACE inhibitors, beta-blockers, or other types of diuretics. Still, you should always consult your healthcare provider before beginning supplementation with any vitamin, mineral, or herbal product.
Many supplements are known to interact with prescription drugs, which is why you should always consult your healthcare provider or pharmacist before taking supplements, including vitamins and herbal remedies.
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Margolis KL, Ray RM, Van horn L, et al. Effect of calcium and vitamin D supplementation on blood pressure: the women's health initiative randomized trial. Hypertension. 2008;52(5):847-55. doi:10.1161/HYPERTENSIONAHA.108.114991
Kim MH, Bu SY, Choi MK. Daily calcium intake and its relation to blood pressure, blood lipids, and oxidative stress biomarkers in hypertensive and normotensive subjects. Nutr Res Pract. 2012;6(5):421-8. doi:10.4162/nrp.2012.6.5.421
Kalra S, Kalra B, Agrawal N. Combination therapy in hypertension: An update. Diabetol Metab Syndr. 2010;2(1):44. doi:10.1186/1758-5996-2-44
Duarte JD, Cooper-dehoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther. 2010;8(6):793-802. doi:10.1586/erc.10.27
Patel AM, Adeseun GA, Goldfarb S. Calcium-alkali syndrome in the modern era. Nutrients. 2013;5(12):4880-93. doi:10.3390/nu5124880
Godfraind T. Discovery and development of calcium channel blockers. Front Pharmacol. 2017;8:286. doi:10.3389/fphar.2017.00286
Zisaki A, Miskovic L, Hatzimanikatis V. Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches. Curr Pharm Des. 2015;21(6):806-22. doi:10.2174/1381612820666141024151119
Pressure tums blood
I turned in my thoughts to the main character of my dreams. Today you eluded me again. Why can't I even talk to you in my sleep.High Blood Pressure Defined
I was close to finish and she understood it, so I sucked more and more actively, swallowing eggs, crushing them, and now, unable to bear such bliss, I poured. Into her mouth, I felt my penis throbbing and filling it, while she did not release it from myself, but was eager to swallow every last drop. At that moment I could not think about anything, everything seemed to freeze around me, but the wave of orgasm that surged.
Through The story is a plot branch of the collection of stories "The Guy from the Country.
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Are you satisfied. - she turned to me. I nodded in the affirmative. Her hand slid over Sergei's stomach and caught his penis, which immediately began to harden.